Pokemon Gold / Silver

System: GMB Publisher: Nintendo Release: 1999/11/21 Lifetime Sales: 6,606,836

New Super Mario Bros.

System: NDS Publisher: Nintendo Release: 2006/05/25 Lifetime Sales: 6,373,965

Pokemon Pearl / Diamond

System: NDS Publisher: Pokemon Co. Release: 2006/09/28 Lifetime Sales: 5,814,251

Pokemon Black / White

System: NDS Publisher: Pokemon Co. Release: 2010/09/18 Lifetime Sales: 5,516,542

Animal Crossing: Wild World

System: NDS Publisher: Nintendo Release: 2005/11/23 Lifetime Sales: 5,284,718

Pokemon Ruby / Sapphire

System: GBA Publisher: Pokemon Co. Release: 2002/11/21 Lifetime Sales: 5,160,765

Brain Age 2: More Training in Minutes a Day!

System: NDS Publisher: Nintendo Release: 2005/12/29 Lifetime Sales: 5,013,321

New Super Mario Bros. Wii

System: WII Publisher: Nintendo Release: 2009/12/03 Lifetime Sales: 4,643,286

Monster Hunter Freedom 3

System: PSP Publisher: Capcom Release: 2010/12/01 Lifetime Sales: 4,532,557

Pokemon X / Y

System: 3DS Publisher: Pokemon Co. Release: 2013/10/12 Lifetime Sales: 4,236,309